Download Alcohol and Hormones by Ronald R. Watson (auth.), Ronald R. Watson (eds.) PDF

By Ronald R. Watson (auth.), Ronald R. Watson (eds.)

Alcoholism, the oldest addictive disease, is still a major challenge as a result of its significant adjustments of many physiological platforms. The genetic and neurological origins and mechanisms are complicated and in basic terms partially understood. in spite of the fact that, it really is transparent that alcohol use modifies the construction of so much hormones, without delay and in some way modulating the platforms that hormones keep watch over. Acute and persistent alcohol intake impacts nearly all mobile features of tissues like mind, liver, immune process, and reproductive and endocrine organs. The latter have significant regula­ tory roles, affecting many capabilities from improvement to repro­ duction. even supposing rigidity can extra adjust alcohol's results on hormone creation, it considerably factors such a lot of alcohol's modi­ fications of the physique to happen through alterations in hormone creation and secretion. Ronald R. Watson vii participants Michael L. Adams • division of Psychiatry, Washington college tuition of drugs, St. Louis, MO Robert A. Anderson, Jr .• Ob/Gyn learn, Rush-Presbyterian-St. Luke's clinical heart, Chicago,IL Kasibhatla Bhavani • Molecular Heptology Laboratory, Massachusetts common medical institution melanoma heart, Harvard scientific college, Charlestown, MA Theodore J. Cicero • division of Psychiatry, Washington collage institution of medication, St.

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Abbreviations EOP, endogenous opioid peptides; U50,448H, trans-(±)3,4-dichloroN-methyl-N-(2-pyrrolidizine-cyclohexyl)-benzeneacetamide methane sulfonate; P-FNA, p-f1unaltrexamine; LH, luteinizing hormone; TSH, thyroid-stimulating hormone; ACTH, adrenocorticotropin; CRF, corticotropin-releasing factor; PRL, prolactin; FSH, follicle-stimulating hormone; H-P-A, hypothalamic-pituitary-adrenal axis; ICV, intracerebroventricular. References IT. 1. Cicero (1980) Effects of exogenous and endogenous opiates on the hypothalamic-pituitary-gonadal axis in the male rat.

Specifically, the rationale underlying this approach is as follows. Binding to a receptor simply indicates that the ligands have affinity for that receptor. From these data alone, it is impossible to discern whether the results of receptor activation reflect agonist or antagonist properties and, more importantly, whether receptor occupancy translates into a physiological relevant event. In order to draw any conclusions regarding the physiological significance of, for example, )l or K receptor binding, it would be necessary to assess postreceptor translational events and their correlation with specific endocrine responses.

Reprod. Fert. 85, 771-793. IJ"A. Bergh, A. A. Bergh, 1. E. Damber, M. Hammar, and G. Selstam (1984) Steroid biosynthesis and Leydig cell morphology in unilaterally cryptorchid rats. Acta Endocrinal. 107,556-562. 137L. A. Dostal, R. E. Chapin, S. A. Stefanski, M. W. Harris, and B. A. Schwetz (1988) Testicular toxicity and reduced Sertoli cell numbers in neonatal rats by di(2-ethylhexyl)phthalate and the recovery of fertility as adults. Taxieo!. Appl. Pharmacol. 95, 104-121. I3HP. Sjoberg, U. Bondesson, L.

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