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By Dorothy H. Crawford

The Epstein-Barr virus (EBV) used to be chanced on in 1964. on the time, the very suggestion of a pandemic underlying a melanoma was once innovative. melanoma is, in spite of everything, no longer catching. Even now, the assumption of a pandemic inflicting melanoma surprises many folks. yet Epstein-Barr, named after its discoverers, Sir Anthony Epstein and Dr Yvonne Barr, is interesting for different purposes too. virtually every person incorporates it, but it's only lower than sure situations that it produces ailment. it's been linked to diverse, it seems that unrelated, ailments in several populations: Burkitt's Lymphoma, generating tumors within the jaw, in African youngsters; a nasal tumor in China; glandular fever in Europe and the us; and nearly all of situations of Hodgkin's sickness in every single place.

This booklet tells the tale of the invention of the virus, and the popularity of its reference to those a variety of ailments -- an account that spans the area and includes a few notable characters and person tales.

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Extra info for Cancer Virus: The discovery of the Epstein-Barr Virus

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The studies that provided the answers are described in the following chapters. *** 38 the eur ek a moment By 1966 Barr had completed her doctoral studies and gained a PhD from the University of London. Following her three years at the Bland-Sutton Institute, Barr married and emigrated to Melbourne, Australia, where she spent 20 years teaching science and maths in state schools. She retired in 1993 and, at the time of writing still lives in Victoria. Achong was awarded an MD by University College, Dublin, for his work on the fine structure of Burkitt Lymphoma cells in 1965.

When Epstein returned to the Bland-Sutton Institute in 1956 he was well equipped to perform pioneering work on viruses. He was the first to show that Rous sarcoma virus had an RNA genome,25 and by mark­ing viruses with tiny gold particles he could actually track them as they found their way in and out of cells. So when, in 1961, the chance came to chase a human tumour virus, Epstein was not just receptive but totally inspired. ’ (Figure 5). Figure 5 The notice announcing Burkitt’s lecture at the Middlesex Hospital in 1961 28 the eur ek a moment After the lecture Burkitt and Epstein were formally introduced and sat down to tea together.

17 Burkitt’s earlier observation of lymphoma in 19 cancer v irus adult migrants into the lymphoma belt could also be explained by this theory as these people were most likely experiencing malaria for the first time, a situation known to cause high levels of blood parasites. All this information supported a causal relationship between the tumour and holoendemic malaria, which was backed up by two further intriguing, albeit anecdotal, observations. The first of these related to sickle cell anaemia.

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