Download Cell Entry by Non-Enveloped Viruses (Current Topics in by John E. Johnson PDF

By John E. Johnson

The skill wherein non-enveloped viruses penetrate mobile membranes in the course of phone access stay poorly outlined. contemporary findings point out numerous individuals of this workforce proportion a standard mechanism of membrane penetration within which the virus particle undergoes programmed conformational alterations, resulting in capsid disassembly and unlock of small membrane-interacting peptides. an entire figuring out of host cellphone access through this minimum approach can assist elucidate the mechanisms of non-enveloped virus membrane penetration normally

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1981). The smaller particles of NV VLPs with a diameter of 23 nm contain the full-length 58-kDa NV capsid protein and are similar antigenically and biochemically to the 38-nm VLPs (White et al. 1997). However, it is interesting to note that the smaller particles must differ in some fundamental way since they are far more sensitive to proteolytic cleavage than the larger, T ¼ 3 particles. It was suggested that the smaller particles are formed from 60 copies of the capsid protein and exhibit a T ¼ 1 symmetry.

28 4 Interaction Between Noroviruses and Polysaccharides . . . . . . . . . . . . . . . . . . 30 5 Attenuation of NMV 1 Pathogenesis . . . . . . . . . . . . . . . . . . . . . . . . . . . 32 6 The Cryo TEM Structure of the T 3 MNV 1 Capsid . . . . . . . . . . . . . . . . . . 33 7 The Cryo TEM Structure of MNV 1 Complexed with Fab’s . . . . . . . . . . . . . . . 35 References . . . . .

5). Detailed characterization of these intermediates and their respective structural rearrangements will provide insights into the mechanism of FHV entry and membrane penetration, which can then be applied to related non-enveloped viruses. 1 The Eluted Particle: A Putative Entry Intermediate During a normal FHV infection, a fraction of virus particles are eluted from cells. These particles, termed eluted particles, are thought to represent a distinct entry intermediate that has undergone some or all of the structural rearrangements that accompany virus entry into the host cell (Figs.

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