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74, 3184-3188. Kwan, S-P, Wood, T. , and Lingrel, J. B. (1977). Proc. Natl. Acad. Sei. A. 74, 178-182. Bastos, R. , and Aviv, H. (1977). Cell 11, 641-650. , and Darnell, J. E. (1977). Cell 10, 611-621. , and Wall, R. (1978). Proc. Natl. Acad. Sei. A. 75, 342-345. Reddy, V. , Subramanian, K. , Zain, B. , Celma, M. , and Weissman, S. M. (manuscript in press). Gilbert, W. (1978). Nature 271, 501. Robertson, H. , and Dunn, J. J. (1977). Proc. Natl. Acad. Sei. A. 74, 822-826. , and Kramer, R. A. (1977).

The nuclear membrane may nevertheless influence attachment points of the genetic material or it may control the uptake of regulators or the release of m-RNAs. Possible alterations of the composition or the turnover of nuclear membrane components during the cell cycle - particularly in view of the above observations - in mitosis or early G]_ were therefore investigated (28) . Purified nuclear envelopes of Chinese hamster ovary cells were found to contain 47 polypeptide bands of which 9 were containing glycoproteins.

All right of reproduction in any form reserved. ISBN 0-12-217850-5 48 4. LAWRENCE A. LOEB et al. INTRODUCTION It is a special pleasure for me to speak at this conference honoring Dr. Daniel Mazia. Firstly, I was a student of Daniel Mazia and have obtained my degree under his auspices. Secondly, many of the ideas that I will discuss were originated during my tenure in his laboratory. In fact, my initial grant application on the fidelity of DNA replication was written some 11 years ago in Dr. Mazia1s laboratory.

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