Download Concepts and techniques in genomics and proteomics by Nachimuthu Saraswathy PDF

By Nachimuthu Saraswathy

Creation to genes and genomes; The human genome venture; Genomes of version organisms; excessive ability vectors; DNA sequencing equipment; Genome mapping; Genome sequencing tools; Genome series meeting and annotation; practical genomics; creation to proteomics; Two-dimensional gel electrophoresis of proteins; Mass spectrometry for proteomics; Protein identity through Peptide Mass Fingerprinting (PMF); Protein sequencing strategies; Phosphoproteomics; Glycoproteomics

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The initial estimate for the HGP was US$200 million per year for 15 years. Rapid progress was made in mapping and sequencing techniques which paved the way for the completion of the HGP ahead of its target schedule 2005. Therefore, the project cost was less than what had been expected. 0 billion. About 50 per cent of the fund was provided by the USA and the rest came from other countries, mainly the UK, France, Germany, Japan, Australia, and Canada. 8 million, respectively. 3 Goals of the HGP The idea behind the HGP was to learn the genetic mechanisms that control the human development from zygote, its interactions with the environment, genetic disorders, the aging process, etc.

This method is known as BAC-based method or clone-by-clone sequencing method. In 1998, a privately funded organization led by Dr Craig 18 Concepts and Techniques in Genomics and Proteomics J. Venter also started human genome sequencing using a separate strategy in which sequencing was done without preparing a high density map, and this is known as the ‘shotgun method’ of sequencing. It became a competition between the publicly funded HGP and the privately funded HGP to complete the human genome sequence.

Coli culture. The developmental pathways of all 957 cells are marked. It has six pairs of chromosomes (2n = 6) and the ratio of autosomes to sex chromosomes determines the sex of C. elegans as male or hermaphrodite. Because of self-fertilization of hermaphrodites, 300 progenies are produced with a uniform genetic identity. It has a comparatively smaller genome (97 Mbp) than humans but 35 per cent of the worm genes have a human homolog. It is well known in gene function studies using the RNAi technique.

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