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By W. Arber, W. Braun, F. Cramer, R. Haas, W. Henle, P. H. Hofschneider, N. K. Jerne, P. Koldovský, H. Koprowski, O. Maaløe, R. Rott, H. G. Schweiger, M. Sela, L. Syru?ek, P. K. Vogt, E. Wecker

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Probably arose spontaneously in a multiple recessive stock. Homozygotes show repeated waves of hair loss and re-growth which begin at the nose and pass posteriorly along the body. Viability and penetrance are good (LYON, 1956). Fu, fused, semidominant. Arose in stocks at the Bussey Institution prior to 1931. Expression of this mutant shows great variability. Both homozygotes and heterozygotes may have shortened and kinked tails or they may both be normal. Homozygotes tend to be more severely affected than heterozygotes.

It is interesting that in the pioneer studies on segregating popUlations of CBA and C 57 mice it has been found that" the differing ability of CBA and C57 mice to make an antibody response to (H, G)-A-L is dominant and in all likelihood due to more than one genetic factor, or to one major genetic factor plus an unknown number of modifiers. This tentative conclusion is based on the observation that in the Fl X C 57 backcross there is not a clear 1:1 Mendelian segregation of C57 and Fl phenotypes" (McDEVITT and SELA, 1967).

BOYSE et al. , whether the presence of one antigen affects the expressivity of the other and whether these relations - if they really exist - will reflect some genetic realities. Thus BOYSE et al. (1968) studied the question of whether the saturation of receptors for any of the five different antigenic systems (TL1, 2, 3; H-2D, K; Ly-A; Ly-B; 0) leads to the reduction of absorption capacity for another antibody. K. 2: TL. 3. Kimplied that on the heterozygous cells theH-2 genes produced, or specifically modified, more than one macromolecule.

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