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By C. Schiepers (auth.), Christiaan Schiepers MD, PhD (eds.)

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Eur J Nucl Med 25:1270-1276 Meyer M, Koeppe A, Frey KA, Foster NL, Kuhl DE (1995) Positron emission tomography measures of benzodiazepine binding in Alzheimer's disease. Arch Neurol 52:314-317 Miletich RS, Chan T, Gillespie M et al. (1988) Contralateral basal ganglia metabolism in abnormal in hemiparkinsonian patients. An FDG-PET study. Neurology 38:S260 Minoshima S, Frey KA, Koeppe RA, Chimowitz MI, McCune WJ, Kuhl DE (1993) Regional discordance between benzodiazepine receptor distribution and glucose metabolism in ischemie cerebral vascular disease.

1992). Overall, these results demonstrate the high sensitivity in localizing seizure foei comparable to that of 18F_FDG PET (70%), but so me 24 G. Lucignani, J. J. Frost studies have shown a lower sensitivity, stimulating with 18p-PDG-PET imaging, SPECT perfusion imaging is more sensitive than MRI (CORDES et al. 1990). the use of ictal SPECT scanning. Due to the longer half-life of SPECT blood flow ra- The presence of interictal hypoperfusion is similarly diopharmaceuticals, the use of ictal and postictal more eommon in patients with T2-weighted MRI abscanning in patients with epilepsy has been explored normalities, as compared with patients with normal in recent years (Magistretti and UREN 1983; LEE et al.

Brain 120:1961-1973 Richardson MP, Koepp MJ, Brooks DJ, Duncan JS (1998) 11C-flumazenil PET in neocortical epilepsy. Neurology 51:485-492 Rinne JO, Laihinen A, Nagren K, Bergman J, Ruotsalainen U, Rinne UK (1990) PET demonstrates different behaviour of striatal dopamine D-l and D-2 receptors in early Parkinson's disease. J Neurosci Res 27:494-499 Risinger MW, Engel J Jr, Van Ness PL, Henry TR (1989) Ictallocalization of temporal lobe seizures with scalp/sphenoidal recordings. Neurology 39:1288-1293 Robitaille Y, Rasmussen T, Dubeau F, Tampieri D, Kemball K (1992) Histopathology of non-neoplastic lesions in frontal lobe epilepsy.

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