By Z. Hochberg, M. C. J. Rudolf, N. Shehadeh, A. Hazani (auth.), Prof. Dr. Sebastiano Andò, Prof. Dr. Carlo Brancati (eds.)
Endocrine glands will be serious about sufferers with thalassemia significant. within the final two decades, new cures have considerably better lifestyles expectancy, whereas numerous endocrine abnormalities were defined in childrens, young people, and teenagers struggling with thalassemia significant.
The functional target of this e-book is to set up instructions for the administration of endocrine problems underlying many of the levels of thalassemic lifestyles. the world over said specialists supply a cutting-edge account of physiopathological and therapeutical techniques to endocrine problems in thalassemia and concentrate on such subject matters as progress hormones, thyroid illnesses, puberty, hypogonadism, diabetes, and bone metabolism.
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Endocrine glands will be fascinated about sufferers with thalassemia significant. within the final twenty years, new remedies have considerably stronger existence expectancy, whereas numerous endocrine abnormalities were defined in kids, children, and teenagers struggling with thalassemia significant. the sensible goal of this ebook is to set up directions for the administration of endocrine problems underlying a number of the stages of thalassemic existence.
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Additional info for Endocrine Disorders in Thalassemia: Physiopathological and Therapeutical Aspects
6. Correlations between age and total sperm count in patients with ~-thalassaemia major Induction of Spermatogenesis After gonadotrophin treatment, eight of 21 patients remained azoospermic, but spermatogenesis was induced in 13 patients with hypogonadism or arrested puberty. Of those 13 patients, four had normal spermatogenesis, one had oligospermia (low sperm count) but good motility, and five had oligoasthenospermia (low sperm count and poor sperm motility). Conclusions In a recent survey of more than 3000 patients the group studying endocrine complications in nonendocrine diseases of the Italian Endocrine Pediatric Society (SIEDP) found some degree of hypogonadism in 45 % of patients, but 55 % entered or com- 24 M.
J Bone Miner Res 5: 645--651 14. DeVernejoul MC, Pointillart A, Golenzer CC et al. (1984) Effects of iron overload on bone remodeling in pigs. Am J Pathol 166: 377 15. Diamond T, Stiel D, Posen S (1989) Osteoporosis in hemochromatosis: iron excess, gonadal deficiency of other factors. Ann Intern Med 110: 430-436 16. Aksoy M, Camli N, Dincol K, Erdem S, Dincol G (1973) On the problem of 'rib-within-a-rib' appearance in thalassemia intermedia. Radiol Clin Bioi 42: 126-133 17. Kattamis C, Touliators N, Haidas S et al.
5 % after amenorrhoea occurred. e. peak number, length, PL and IPI, were similar in the two groups. The development of abnormal pulse parameters following the onset of amenorrhoea is indicative of H-P dysfunction. At 5-6 Years After the Onset of Amenorrhoea Although patients studied at 12 -14 months who had pulse defects all were pulsatile, by 5-6 years 66% of patients had become apulsatile. The remaining 3-4 remained pulsatile but their pulse parameters deteriorated, in that they exhibited multiple pulse defects.