By F. A. Langley M.Sc., M.D., F.R.C.Path., F.R.C.O.G., A. C. Crompton M.D., F.R.C.S.Ed., M.R.C.O.G. (auth.)
The advent of colposcopy and exfoliative cytology as a method of reading the cervix uteri has spread out the opportunity of learning the previous and early phases of invasive carcinoma of the cervix and has additionally dropped at mild a couple of stipulations that are probably simply in a roundabout way comparable, if comparable in any respect, to cervical neo with histological evaluate it's attainable to plasia. utilizing those tools mixed achieve a few perception into the common background of cervical carcinoma. the significance of this isn't restricted to the cervix for, during this appreciate, the cervical lesions may possibly turn out a paradigm for these of the bladder, belly and somewhere else. at the moment the vast define of the common historical past of those cervical lesions is rising however the temporal and spatial relationships of some of the stages is doubtful, principally as a result of variety of chances envisaged which includes extra vari ables than may be managed in an individual research. during this monograph we've endeavoured to point the constraints of a few of the methods and to emphasize the necessity for controlling the accuracy of evaluation even if it's histological, cytological or colposcopic.
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Extra info for Epithelial Abnormalities of the Cervix Uteri
HARTMANN (1962) has described convincing evidence of cyclical changes in the endocervix of the monkey. 4. The Stroma of the Cervix a) The Histological Pattern DANFORTH (1947) and DANFORTH and CHAPMAN (1950) have shown that the stroma of the cervix is predominantly composed of fibrous connective tissue but smooth muscle and elastic tissue are also present, although in smaller amounts than had previously been supposed. The transition from the fibrous tissue of the cervix to the muscular tissue of the corpus is usually abrupt but sometimes it is gradual.
MEYER (1910a and b) believed that primitive endodermal cells with the potency to develop into squamous elements could be present in the columnar epithelium. EICHHOLZ (1902) thought that embryonic undifferentiated cells could persist as inclusions. These cells were thought to retain the potentiality of developing into either columnar or squamous epithelium. This possibility has been discussed by GELLER (1923), CARMICHAEL and JEAFFRESON (1939, 1941), AUERBACH and PUND (1945), TOPKINS (1949), HOWARD et ai.
The columnar cells have been totally replaced by squamoid epithelium which shows some stratification. (H. & E. X 360) , . Fig. 11. An isolated plaque of metaplastic squamous epithelium. (H. & E. X 60) The terms complete and incomplete metaplasia refer to the maturity of the metaplastic process and not to its extent. In the final stage of metaplasia the normal strata of well-differentiated epithelium can be seen. At this stage preceding metaplasia can be recognised by a waviness of the base, pegs of epithelium dipping Bland Abnormalities of Squamous Epithelium 45 Fig.