By Marc Daeron, Falk Nimmerjahn (eds.)
This quantity offers a state of the art replace on Fc Receptors (FcRs). it really is divided into 5 elements. half I, Old and New FcRs, offers with the long-sought-after FcµR and the lately stumbled on FCRL family members and TRIM21. half II, FcR Signaling, provides a computational version of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. half III, FcR Biology, addresses significant physiological capabilities of FcRs, their glycosylation, how they set off and control either adaptive immune responses and irritation, specifically in vivo, FcR humanized mice, and the multifaceted homes of FcRn. half IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and no matter if their FcRs make macaques reliable versions for learning HIV an infection. partially V, FcRs and healing Antibodies, the jobs of assorted FcRs, together with FcγRIIB and FcαRI, within the immunotherapy of melanoma and autoimmune illnesses utilizing monoclonal antibodies and IVIg are highlighted. All 18 chapters have been written via revered specialists of their fields, delivering a useful reference resource for scientists and clinicians drawn to FcRs and the way to raised grasp antibodies for healing purposes.
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Extra info for Fc Receptors
PERK additionally induces expression of the BLIMP1 plasma cell commitment factor that stimulates B cell differentiation and Ab production. By contrast, simultaneous crosslinking of FCRL3 with receptor-specific mAbs in TLR9 activated B cells significantly elevates whole pTyr, p-p65, pERK, and p38 to promote proliferation and survival. However, augmented pERK activation in TLR9/FCRL3 co-stimulated B cells represses BLIMP1 induction and abrogates plasma cell differentiation and Ab production Accordingly, these repressive components attenuate antigen receptor-mediated calcium mobilization and MAPK activation.
The first domain of FCRLA appears to be a degenerate Ig-like subunit and is thus truncated in the figure. The type-B cysteine-rich scavenger receptor domain (Sc) of mouse FCRLS and mucin-like regions (triangles) of FCRLA and FCRLB are also specified. FCRL1-6 cytoplasmic tails possess potential consensus ITIM (L/V/I)-X-Y-X-X-(L/V/I) (red boxes), ITAM-like (E/D)-X-X-Y-X-X(L/I)-X6-8-Y-X-X-(L/I) (green boxes), and ITSM (S/T)-X-Y-X-X-(V/I) (orange box) sequences. The expression patterns among B cells include memory (Mem), circulating (Circ) and tissue-based (Tis) marginal zone (MZ), plasma cell (PC), germinal center (GC), and follicular (FO) subsets.
This mini-review article is heavily indebted to the early studies of IgM-binding proteins by three outstanding post-doctoral fellows in the laboratory of Dr. Max Cooper: Sheila K. Sanders, Tatsuharu Ohno and Tetsuya Nakamura. HK also would like to dedicate this paper as a token of his immense gratitude to his respected mentor Dr. Max Cooper, Georgia Research Alliance Eminent Scholar, Professor of Pathology and Laboratory Medicine, Emory University School of Medicine, for his great advice and long support.