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By Z. S. Khachaturian (auth.), Prof. Dr. Francois Boller, F. Forette, Z. S. Khachaturian, Michel Poncet, Yves Christen PH. D. (eds.)

The time period "Alzheimer's ailment" is at the moment used to consult senile and in addition presenile dementia, however the heterogeneity of this affliction is verified in lots of of its features. this can be of serious theoretical curiosity, and with the looks of recent healing interventions, it might additionally begin to have very major useful value. To shed a few gentle at the debate, the Fondation Ipsen equipped a global symposium which came about on April 6, 1992. This quantity comprises the complaints of this assembly, which was once attended by means of researchers in epidemiology, scientific neurology and geriatrics, neuropsychology, neuropathology, molecular biology, and genetics.

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Clin Neuropathol 9:254-261 32 J. Grafman Lopez OL, Becker JT, Brenner RP, Rosen J, Bajulaige 01, Reynolds CF (1991) Alzheimer's disease with delusions and hallucinations: neuropsychological and electroencephalographic correlates. Neurology 41:906-912 Martin A (1987) Representation of semantic and spatial knowledge in Alzheimer's patients: implications for models of preserved learning in amnesia. J Clin Exp Neurophsychol 9:191-224 Martin A (1990) Neuropsychology of Alzheimer's Disease: The Case for Subgroups.

Data- 30 J. Grafman driven knowledge, such as the ability to simply read a word, appears relatively preserved, even during the later stages of AD. This loss of semantic or conceptually driven knowledge is progressive but slow. The patient may be aware of his or her disappearing knowledge store to some degree but cannot easily compensate for its loss. , 1990). This pathophysiological process reduces the number of functioning cells within a regional cortical networks as well as degrading the inter-regional communication and binding process.

It is, therefore, of the upmost importance to consider the fact that the neuropsychological manifestations of AD in the early stages of the disease also do not appear to be homogeneous. It is the purpose of this chapter to provide a brief overview of the literature on this topic and to show that, in AD, the heterogeneity of the neuropsychological manifestations is probably greater than expected, not only when comparing different cognitive functions but also when considering the sUb-components of a given cognitive function.

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