By Geo. F. Brooks, Karen C. Carroll, Janet S. Butel, Stephen A. Morse
The twenty-sixth variation of Jawetz, Melnick & Adelberg’s clinical Microbiology grants a concise, updated evaluate of the jobs microorganisms play in human wellbeing and fitness and sickness. Linking primary rules with the analysis and therapy of microbial infections, this vintage textual content has been up-to-date all through to mirror the large growth of scientific wisdom that has taken position because the final version released. in addition to short descriptions of every organism, you'll find important views on pathogenesis, diagnostic laboratory exams, medical findings, therapy , and epidemiology. The publication additionally contains a whole bankruptcy of case reviews that specializes in differential analysis and administration of microbial infections.
Jawetz, Melnick & Adelberg’s scientific Microbiology, 26e introduces you to uncomplicated medical microbiology in the course of the fields of bacteriology, virology, mycology, and parasitology, supplying you with an intensive but comprehensible evaluation of the self-discipline.
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Additional info for Jawetz, Melnick & Adelberg's Medical Microbiology
28 SECTION I Fundamentals of Microbiology varies widely from one gram-negative species to another; in P aeruginosa, for example, which is extremely resistant to antibacterial agents, the outer membrane is 100 times less permeable than that of E coli. The major proteins of the outer membrane, named according to the genes that code for them, have been placed into several functional categories on the basis of mutants in which they are lacking and on the basis of experiments in which purified proteins have been reconstituted into artificial membranes.
Edwin S. ) Bacterial flagella are thread-like appendages composed entirely of protein, 12–30 nm in diameter. They are the organs of locomotion for the forms that possess them. Three types of arrangement are known: monotrichous (single polar flagellum), lophotrichous (multiple polar flagella), and peritrichous (flagella distributed over the entire cell). The three types are illustrated in Figure 2-24. CHAPTER 2 Cell Structure 33 TABLE 2-1 Chemical Composition of the Extracellular Polymer in Selected Bacteria Organism Polymer Chemical Subunits Bacillus anthracis Polypeptide d-Glutamic Enterobacter aerogenes Complex polysaccharide Glucose, fucose, glucuronic acid Haemophilus influenzae Serogroup b Ribose, ribitol, phosphate Neisseria meningitidis Homopolymers and heteropolymers, eg, acid Serogroup A Partially O-acetylated N-acetylmannosaminephosphate Serogroup B N-Acetylneuraminic acid (sialic acid) Serogroup C Acetylated sialic acid Serogroup 135 Galactose, sialic acid Pseudomonas aeruginosa Alginate d-Manuronic Streptococcus pneumoniae Complex polysaccharide (many types), eg, (pneumococcus) Type II Rhamnose, glucose, glucuronic acid Type III Glucose, glucuronic acid Type VI Galactose, glucose, rhamnose Type XIV Galactose, glucose, N-acetylglucosamine Type XVIII Rhamnose, glucose Streptococcus pyogenes (group A) Hyaluronic acid N-Acetylglucosamine, glucuronic acid Streptococcus salivarius Levan Fructose A acid, l-glucuronic acid B Figure 2-23 Bacterial capsules.
Some Archaeal cell membranes contain unique lipids, isoprenoids, rather than fatty acids, linked to glycerol by ether rather than an ester linkage. Some of these lipids have no phosphate groups, and therefore, they are not phospholipids. In other species, the cell membrane is made up of a lipid monolayer consisting of long lipids (about twice as long as a phospholipid) with glycerol ethers at both ends (diglycerol tetraethers). The molecules orient themselves with the polar glycerol groups on the surfaces and the nonpolar hydrocarbon chain in the interior.