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Benzothiazoles are highly interesting molecules for drug development, because they already have been shown to be useful for treating cerebrovascular and neurodegenerative disorders. For example, riluzole extends the survival of neurons in amyotrophic lateral sclerosis patients (28, 29). It also has been tested for therapy of HD patients, where treatment with riluzole has positive effects on choreatic hyperkinesia (30). Moreover, it has been reported that riluzole leads to an extended lifespan in a mouse model of HD (31).

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