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Additional info for Second Primary Cancers and Cardiovascular Disease After Radiation Therapy
In addition, since there is no external control group, only internal comparisons are available in a case-control study. However, with enhanced treatment data, internal comparisons can be much more informative than in studies with more limited data (such as most registry-based cohort studies). For a comprehensive review of the potential biases and limitations of radiation epidemiology studies, the reader is referred to the 2006 UNSCEAR report (UNSCEAR, 2008). , the number of newly diagnosed cases per 100,000 person-years (PY)].
There is also some evidence that cancer preventive agents can work in people when given after the radiation exposure. At time periods of several months to years after the Chernobyl nuclear reactor accident, efforts began to provide potassium iodide in the form of dietary supplements (as antistrumin, multivitamins containing iodine and iodized salt) to children from exposed areas. , 2005). 4 Drugs Used in Cancer Therapy. Many of the drugs used in cancer therapy procedures are known to be highly carcinogenic and capable of inducing SPCs in patients being treated for an existing cancer.
This section is meant as a brief overview, not a comprehensive discussion, of the so-called “nontargeted” and “out-of-field” effects of radiation. 1 Bystander Responses. The radiation-induced bystander response is the occurrence of biological changes in unirradiated cells that are in proximity to or sharing local environment with cells that have been traversed by ionizing radiation. In the context of this Report, bystander effects may be relevant if their occurrence in tissues expands the size of the target for radiation-induced damages to a tissue volume greater than that actually irradiated.